While erythritol has traditionally been regarded as a low-toxicity sugar alcohol according to subchronic and reproductive toxicity studies, recent findings from non-nutritive sweetener research indicate that metabolic context, redox signaling, and developmental phases can significantly alter biological effects ( At the systemic level, the body weights and offspring numbers of F1 and F2 progeny did not significantly differ from the controls ( Figures 1AD ), indicating that erythritol exposure did not result in overt growth restriction or substantial fertility failure
doi: 10.1021/acs.jmedchem.0c01107 Ryan, Rachael Y
However, A plaques in these spaces can lead to reduced expression of AQP4 at the astrocytic end-feet, adversely affecting A efflux with the ISF and exacerbating intraparenchymal A deposition [58, 173, 174]
NAC did, however, improve steroid-resistant acute asthma exacerbations in animal models [49]